AB0840 Scleroderma classification criteria: Disease-specific methods for valid case comparisons
Identifieur interne : 000374 ( Canada/Analysis ); précédent : 000373; suivant : 000375AB0840 Scleroderma classification criteria: Disease-specific methods for valid case comparisons
Auteurs : S. R. Johnson [Canada] ; R. L. Naden [Nouvelle-Zélande] ; J. Fransen ; F. Van Den Hoogen [Pays-Bas] ; J. E. Pope [Royaume-Uni] ; M. Baron [Canada] ; M. Matucci-Cerinic [Italie] ; A. Tyndall ; O. Distler [Suisse] ; C. Denton [Royaume-Uni] ; A. Gabrielli [Italie] ; J. Van Laar [Royaume-Uni] ; M. Mayes [États-Unis] ; V. Steen ; J. Seibold ; P. Clements [États-Unis] ; T. Medsger [États-Unis] ; P. Carreira [Espagne] ; G. Riemekasten [Allemagne] ; D. Khanna [États-Unis]Source :
- Annals of the Rheumatic Diseases [ 0003-4967 ] ; 2013-06.
English descriptors
- KwdEn :
- Teeft :
Abstract
Background Classification criteria for systemic sclerosis (SSc) are being developed. Twenty-three candidate criteria have been identified and validated. Standardized cases need to be developed for criteria reduction and possible weighting. Objectives To develop and test SSc-specific case forms for clarity and feasibility. We secondarily explored the agreement between SSc experts on the probability that cases were classified as SSc. Methods Standardized forms were developed using: skin thickening; nailfold capillary pattern; finger tip ulcers/pitting scars; Raynaud’s phenomenon; interstitial lung disease; renal crisis; reduced DLCO; reduced FVC; dysphagia, esophageal dilation; telangiectasia; flexion contractures; pulmonary hypertension; puffy fingers; pulp loss/acro-osteolysis; gastroesophageal reflux; calcinosis; tendon/bursal friction rubs; topoisomerase-I, centromere, RNA polymerase III, antinuclear or PM-ScL antibodies. Six experts tested 6 cases and the ranking procedure for clarity of the instructions, response option and time-to-completion. The forms were applied to purposively sampled SSc cases from international cohorts covering a wide range of probabilities that each case had SSc. Eight experts rank-ordered 20 cases from 1 (highest) to 20 (lowest). The consistency in rankings was evaluated using an intraclass correlation coefficient (ICC). Results 83% (5/6) endorsed clarity of the form, 100% (6/6) clarity of the instructions, and 100% (6/6) clarity of the response option. The median time-to-completion was 10 minutes (range 10–20). The ICC for agreement across experts was 0.73 (95% CI 0.58, 0.86). Conclusions Our SSc-specific forms have demonstrable clarity and feasibility. Using these cases, the expert panel had substantial agreement in rank order. Our methods reflect the rigors of modern psychometric science, and serves as a template for groups developing classification criteria. Disclosure of Interest None Declared
Url:
DOI: 10.1136/annrheumdis-2012-eular.840
Affiliations:
- Allemagne, Canada, Espagne, Italie, Nouvelle-Zélande, Pays-Bas, Royaume-Uni, Suisse, États-Unis
- Angleterre, Berlin, Californie, Communauté de Madrid, Grand Londres, Gueldre, Ontario, Pennsylvanie, Québec, Texas
- Berlin, Houston, Londres, Los Angeles, Madrid, Montréal, Nimègue, Pittsburgh, Toronto
- Université McGill, Université de Pittsburgh, Université de Toronto
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R." last="Johnson">S. R. Johnson</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Naden, R L" sort="Naden, R L" uniqKey="Naden R" first="R. L." last="Naden">R. L. 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Matucci-Cerinic</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>University of Florence, Firenze</wicri:regionArea><wicri:noRegion>Firenze</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>University of Florence, Firenze</wicri:regionArea><wicri:noRegion>Firenze</wicri:noRegion></affiliation></author><author><name sortKey="Tyndall, A" sort="Tyndall, A" uniqKey="Tyndall A" first="A." last="Tyndall">A. Tyndall</name><affiliation></affiliation><affiliation><wicri:noCountry code="subField">Basel</wicri:noCountry></affiliation></author><author><name sortKey="Distler, O" sort="Distler, O" uniqKey="Distler O" first="O." last="Distler">O. 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Gabrielli</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Università Politecnica delle Marche, Ancona</wicri:regionArea><wicri:noRegion>Ancona</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Università Politecnica delle Marche, Ancona</wicri:regionArea><wicri:noRegion>Ancona</wicri:noRegion></affiliation></author><author><name sortKey="Van Laar, J" sort="Van Laar, J" uniqKey="Van Laar J" first="J." last="Van Laar">J. Van Laar</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Newcastle, Newcastle</wicri:regionArea><wicri:noRegion>Newcastle</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Newcastle, Newcastle</wicri:regionArea><wicri:noRegion>Newcastle</wicri:noRegion></affiliation></author><author><name sortKey="Mayes, M" sort="Mayes, M" uniqKey="Mayes M" first="M." last="Mayes">M. Mayes</name><affiliation wicri:level="3"><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><wicri:orgArea>University of Texas</wicri:orgArea></affiliation><affiliation wicri:level="3"><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><wicri:orgArea>University of Texas</wicri:orgArea></affiliation></author><author><name sortKey="Steen, V" sort="Steen, V" uniqKey="Steen V" first="V." last="Steen">V. Steen</name><affiliation></affiliation><affiliation><wicri:noCountry code="subField">Georgetown</wicri:noCountry></affiliation></author><author><name sortKey="Seibold, J" sort="Seibold, J" uniqKey="Seibold J" first="J." last="Seibold">J. Seibold</name><affiliation></affiliation><affiliation><wicri:noCountry code="subField">Avon</wicri:noCountry></affiliation></author><author><name sortKey="Clements, P" sort="Clements, P" uniqKey="Clements P" first="P." last="Clements">P. Clements</name><affiliation wicri:level="3"><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName><wicri:orgArea>UCLA</wicri:orgArea></affiliation><affiliation wicri:level="3"><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName><wicri:orgArea>UCLA</wicri:orgArea></affiliation></author><author><name sortKey="Medsger, T" sort="Medsger, T" uniqKey="Medsger T" first="T." last="Medsger">T. Medsger</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Carreira, P" sort="Carreira, P" uniqKey="Carreira P" first="P." last="Carreira">P. Carreira</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Riemekasten, G" sort="Riemekasten, G" uniqKey="Riemekasten G" first="G." last="Riemekasten">G. Riemekasten</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Leibniz Institute, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Leibniz Institute, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Khanna, D" sort="Khanna, D" uniqKey="Khanna D" first="D." last="Khanna">D. Khanna</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Michigan, Ann Arbor</wicri:regionArea><wicri:noRegion>Ann Arbor</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Michigan, Ann Arbor</wicri:regionArea><wicri:noRegion>Ann Arbor</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of the Rheumatic Diseases</title><title level="j" type="abbrev">Ann Rheum Dis</title><idno type="ISSN">0003-4967</idno><idno type="eISSN">1468-2060</idno><imprint><publisher>BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><date type="published" when="2013-06">2013-06</date><biblScope unit="volume">71</biblScope><biblScope unit="issue">Suppl 3</biblScope><biblScope unit="page" from="686">686</biblScope></imprint><idno type="ISSN">0003-4967</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0003-4967</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Hospital universitario</term><term>Internal medicine</term><term>Rheumatology</term><term>Sclerosis</term><term>Systemic sclerosis</term><term>Tokai university school</term><term>Yokohama city university</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Hospital universitario</term><term>Internal medicine</term><term>Rheumatology</term><term>Sclerosis</term><term>Systemic sclerosis</term><term>Tokai university school</term><term>Yokohama city university</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Background Classification criteria for systemic sclerosis (SSc) are being developed. Twenty-three candidate criteria have been identified and validated. Standardized cases need to be developed for criteria reduction and possible weighting. Objectives To develop and test SSc-specific case forms for clarity and feasibility. We secondarily explored the agreement between SSc experts on the probability that cases were classified as SSc. Methods Standardized forms were developed using: skin thickening; nailfold capillary pattern; finger tip ulcers/pitting scars; Raynaud’s phenomenon; interstitial lung disease; renal crisis; reduced DLCO; reduced FVC; dysphagia, esophageal dilation; telangiectasia; flexion contractures; pulmonary hypertension; puffy fingers; pulp loss/acro-osteolysis; gastroesophageal reflux; calcinosis; tendon/bursal friction rubs; topoisomerase-I, centromere, RNA polymerase III, antinuclear or PM-ScL antibodies. Six experts tested 6 cases and the ranking procedure for clarity of the instructions, response option and time-to-completion. The forms were applied to purposively sampled SSc cases from international cohorts covering a wide range of probabilities that each case had SSc. Eight experts rank-ordered 20 cases from 1 (highest) to 20 (lowest). The consistency in rankings was evaluated using an intraclass correlation coefficient (ICC). Results 83% (5/6) endorsed clarity of the form, 100% (6/6) clarity of the instructions, and 100% (6/6) clarity of the response option. The median time-to-completion was 10 minutes (range 10–20). The ICC for agreement across experts was 0.73 (95% CI 0.58, 0.86). Conclusions Our SSc-specific forms have demonstrable clarity and feasibility. Using these cases, the expert panel had substantial agreement in rank order. Our methods reflect the rigors of modern psychometric science, and serves as a template for groups developing classification criteria. Disclosure of Interest None Declared</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>Espagne</li><li>Italie</li><li>Nouvelle-Zélande</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Berlin</li><li>Californie</li><li>Communauté de Madrid</li><li>Grand Londres</li><li>Gueldre</li><li>Ontario</li><li>Pennsylvanie</li><li>Québec</li><li>Texas</li></region><settlement><li>Berlin</li><li>Houston</li><li>Londres</li><li>Los Angeles</li><li>Madrid</li><li>Montréal</li><li>Nimègue</li><li>Pittsburgh</li><li>Toronto</li></settlement><orgName><li>Université McGill</li><li>Université de Pittsburgh</li><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Fransen, J" sort="Fransen, J" uniqKey="Fransen J" first="J." last="Fransen">J. Fransen</name><name sortKey="Seibold, J" sort="Seibold, J" uniqKey="Seibold J" first="J." last="Seibold">J. Seibold</name><name sortKey="Steen, V" sort="Steen, V" uniqKey="Steen V" first="V." last="Steen">V. Steen</name><name sortKey="Tyndall, A" sort="Tyndall, A" uniqKey="Tyndall A" first="A." last="Tyndall">A. Tyndall</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Johnson, S R" sort="Johnson, S R" uniqKey="Johnson S" first="S. R." last="Johnson">S. R. Johnson</name></region><name sortKey="Baron, M" sort="Baron, M" uniqKey="Baron M" first="M." last="Baron">M. Baron</name><name sortKey="Baron, M" sort="Baron, M" uniqKey="Baron M" first="M." last="Baron">M. Baron</name><name sortKey="Johnson, S R" sort="Johnson, S R" uniqKey="Johnson S" first="S. R." last="Johnson">S. R. Johnson</name></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Naden, R L" sort="Naden, R L" uniqKey="Naden R" first="R. L." last="Naden">R. L. Naden</name></noRegion><name sortKey="Naden, R L" sort="Naden, R L" uniqKey="Naden R" first="R. L." last="Naden">R. L. Naden</name></country><country name="Pays-Bas"><region name="Gueldre"><name sortKey="Van Den Hoogen, F" sort="Van Den Hoogen, F" uniqKey="Van Den Hoogen F" first="F." last="Van Den Hoogen">F. Van Den Hoogen</name></region><name sortKey="Van Den Hoogen, F" sort="Van Den Hoogen, F" uniqKey="Van Den Hoogen F" first="F." last="Van Den Hoogen">F. Van Den Hoogen</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Pope, J E" sort="Pope, J E" uniqKey="Pope J" first="J. E." last="Pope">J. E. Pope</name></region><name sortKey="Denton, C" sort="Denton, C" uniqKey="Denton C" first="C." last="Denton">C. Denton</name><name sortKey="Denton, C" sort="Denton, C" uniqKey="Denton C" first="C." last="Denton">C. Denton</name><name sortKey="Pope, J E" sort="Pope, J E" uniqKey="Pope J" first="J. E." last="Pope">J. E. Pope</name><name sortKey="Van Laar, J" sort="Van Laar, J" uniqKey="Van Laar J" first="J." last="Van Laar">J. Van Laar</name><name sortKey="Van Laar, J" sort="Van Laar, J" uniqKey="Van Laar J" first="J." last="Van Laar">J. Van Laar</name></country><country name="Italie"><noRegion><name sortKey="Matucci Cerinic, M" sort="Matucci Cerinic, M" uniqKey="Matucci Cerinic M" first="M." last="Matucci-Cerinic">M. Matucci-Cerinic</name></noRegion><name sortKey="Gabrielli, A" sort="Gabrielli, A" uniqKey="Gabrielli A" first="A." last="Gabrielli">A. Gabrielli</name><name sortKey="Gabrielli, A" sort="Gabrielli, A" uniqKey="Gabrielli A" first="A." last="Gabrielli">A. Gabrielli</name><name sortKey="Matucci Cerinic, M" sort="Matucci Cerinic, M" uniqKey="Matucci Cerinic M" first="M." last="Matucci-Cerinic">M. Matucci-Cerinic</name></country><country name="Suisse"><noRegion><name sortKey="Distler, O" sort="Distler, O" uniqKey="Distler O" first="O." last="Distler">O. Distler</name></noRegion><name sortKey="Distler, O" sort="Distler, O" uniqKey="Distler O" first="O." last="Distler">O. 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Medsger</name></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Carreira, P" sort="Carreira, P" uniqKey="Carreira P" first="P." last="Carreira">P. Carreira</name></region><name sortKey="Carreira, P" sort="Carreira, P" uniqKey="Carreira P" first="P." last="Carreira">P. Carreira</name></country><country name="Allemagne"><region name="Berlin"><name sortKey="Riemekasten, G" sort="Riemekasten, G" uniqKey="Riemekasten G" first="G." last="Riemekasten">G. Riemekasten</name></region><name sortKey="Riemekasten, G" sort="Riemekasten, G" uniqKey="Riemekasten G" first="G." last="Riemekasten">G. Riemekasten</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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